A two-shot or multi-shot multi-material injection molding process is provided. The process allows dissimilar materials to be injection molded to form a single, injection molded part by creating a structural interlock between the materials to prevent the materials from separating. The structural interlock is formed by forming at least one interlock cavity adjacent to a interfacial surface of a first portion of a molded part molded from a first material, and injecting a second, different material into the mold so that the second material flows into the interlock cavity and fills it. Solidification of the second material in the interlock cavity formed by the first material creates the structural interlock between the two materials.