Invention Grant
- Patent Title: Method to block the infection by flaviviruses, molecules and uses
- Patent Title (中): 阻止黄病毒,分子和用途感染的方法
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Application No.: US12298808Application Date: 2007-04-26
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Publication No.: US08420311B2Publication Date: 2013-04-16
- Inventor: Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
- Applicant: Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
- Applicant Address: CU Ciudad de La Habana
- Assignee: Centro de Ingenieria Genetica y Biotecnologia
- Current Assignee: Centro de Ingenieria Genetica y Biotecnologia
- Current Assignee Address: CU Ciudad de La Habana
- Agency: Hoffmann & Baron, LLP
- Priority: CU2006-0091 20060428
- International Application: PCT/CU2007/000014 WO 20070426
- International Announcement: WO2007/124698 WO 20071108
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; A61K39/12

Abstract:
The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
Public/Granted literature
- US20110212105A1 METHOD TO BLOCK THE INFECTION BY FLAVIVIRUSES, MOLECULES AND USES Public/Granted day:2011-09-01
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