Invention Grant
US08420352B2 Protein delivery system to generate pluripotent stem (iPS) cells or tissue specific cells
有权
产生多能干细胞或组织特异性细胞的蛋白质递送系统
- Patent Title: Protein delivery system to generate pluripotent stem (iPS) cells or tissue specific cells
- Patent Title (中): 产生多能干细胞或组织特异性细胞的蛋白质递送系统
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Application No.: US12870782Application Date: 2010-08-27
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Publication No.: US08420352B2Publication Date: 2013-04-16
- Inventor: George A. Oyler , Yung-Nien Chang
- Applicant: George A. Oyler , Yung-Nien Chang
- Applicant Address: US MD Baltimore
- Assignee: Synaptic Research, LLC
- Current Assignee: Synaptic Research, LLC
- Current Assignee Address: US MD Baltimore
- Agency: Whiteford, Taylor & Preston, LLP
- Agent Joseph L. Morales
- Main IPC: C07K14/33
- IPC: C07K14/33 ; C12N1/20 ; C12N15/62 ; C12P21/02
Abstract:
A novel protein delivery system to generate induced pluripotent stem (iPS) cells is described. The delivery system comprises a construct with a receptor binding domain that recognizes a receptor in a somatic cell, a translocation domain that allows the transfer of an inducer into the cytosolic space, and a cargo bearing domain to which the inducer is attached and facilitates transfer of the inducer into the cell.
Public/Granted literature
- US20110053244A1 NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS Public/Granted day:2011-03-03
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