Invention Grant
- Patent Title: Polypeptide having phytase activity and increased temperature resistance of the enzyme activity, and nucleotide sequence coding said polypeptide
- Patent Title (中): 具有植酸酶活性和酶活性耐温度升高的多肽以及编码所述多肽的核苷酸序列
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Application No.: US12312381Application Date: 2007-11-02
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Publication No.: US08420369B2Publication Date: 2013-04-16
- Inventor: Khanh Q. Nguyen , Bruno Winter
- Applicant: Khanh Q. Nguyen , Bruno Winter
- Applicant Address: DE Darmstadt
- Assignee: AB Enzymes GmbH
- Current Assignee: AB Enzymes GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Edwards Wildman Palmer LLP
- Agent Peter F. Corless; Christine C. O'Day
- Priority: DE102006053059 20061110
- International Application: PCT/EP2007/009522 WO 20071102
- International Announcement: WO2008/055625 WO 20080515
- Main IPC: C12N9/16
- IPC: C12N9/16
Abstract:
The invention relates to a recombinant DNA molecule encoding a polypeptide having phytase activity and increased temperature stability and increased proteolytic stability of the enzyme activity. The DNA sequence has been obtained by variation of the mature wild-type E. coli phytase sequence with defined amino acid positions being modified in comparison to the wild-type sequence or with the sequences having N- and/or C-terminal extensions, respectively. The invention further relates to a method for expressing the recombinant phytase as well as its use in the food and animal feed technologies.
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