Invention Grant
US08420631B2 6-substituted-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists
失效
6-取代-2,3,4,5-四氢-1H-苯并[d]吖庚因，为5-HT 2C受体激动剂
![6-substituted-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists](/docs/US/2013-04-16/US08420631B2/abs.jpg.600x600.jpg)
- Patent Title: 6-substituted-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists
- Patent Title (中): 6-取代-2,3,4,5-四氢-1H-苯并[d]吖庚因，为5-HT 2C受体激动剂
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Application No.: US11995344Application Date: 2006-09-01
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Publication No.: US08420631B2Publication Date: 2013-04-16
- Inventor: John Gordon Allen , Karin Briner , Anne Marie Camp , Manuel Javier Cases-Thomas , Richard Charles Hoying , Maria Angeles Martinez-Grau , Michael Philip Mazanetz , Natalia Pokrovskaia , Richard Edmund Rathmell , Roger Ryan Rothhaar , Selma Sapmaz , Andrew Caerwyn Williams
- Applicant: John Gordon Allen , Karin Briner , Anne Marie Camp , Manuel Javier Cases-Thomas , Richard Charles Hoying , Maria Angeles Martinez-Grau , Michael Philip Mazanetz , Natalia Pokrovskaia , Richard Edmund Rathmell , Roger Ryan Rothhaar , Selma Sapmaz , Andrew Caerwyn Williams
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent R. Craig Tucker
- International Application: PCT/US2006/034430 WO 20060901
- International Announcement: WO2007/028131 WO 20070308
- Main IPC: A61P3/04
- IPC: A61P3/04 ; A61P25/00 ; A61P25/22 ; A61P25/24 ; A61K31/55 ; C07D223/16 ; C07D401/06 ; C07D403/04 ; C07D409/04 ; C07D417/06
![6-substituted-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists](/abs-image/US/2013/04/16/US08420631B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where R6 is —C≡C—R10, —CH═CR11R11′, or —(C0-C8)alkyl-Ar2 optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents and other substituents are as defined in the specification.
Public/Granted literature
- US20080207897A1 6-Substituted-2,3,4,5-Tetrahydro-1H-Benzo[D] Azepines as 5-Ht2c Receptro Agonists Public/Granted day:2008-08-28
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