Invention Grant
US08420662B2 Stable solid preparation containing 4,5-epoxymorphinan derivative
有权
稳定的固体制剂含有4,5-环氧基吗啡喃衍生物
- Patent Title: Stable solid preparation containing 4,5-epoxymorphinan derivative
- Patent Title (中): 稳定的固体制剂含有4,5-环氧基吗啡喃衍生物
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Application No.: US12597475Application Date: 2008-04-25
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Publication No.: US08420662B2Publication Date: 2013-04-16
- Inventor: Suguru Takaki , Kotoe Ohta , Yasuhide Horiuchi , Masato Kobayashi , Junko Kawasaki , Eijiro Horisawa
- Applicant: Suguru Takaki , Kotoe Ohta , Yasuhide Horiuchi , Masato Kobayashi , Junko Kawasaki , Eijiro Horisawa
- Applicant Address: JP Tokyo
- Assignee: Toray Industries, Inc.
- Current Assignee: Toray Industries, Inc.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2007-116721 20070426
- International Application: PCT/JP2008/058111 WO 20080425
- International Announcement: WO2008/133330 WO 20081106
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K9/00 ; A61K9/16 ; A61K9/20
Abstract:
It is an object of the present invention to provide a stable solid preparation comprising a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof as an effective ingredient.That is, the present invention provides the stable solid preparation comprising the 4,5-epoxymorphinan derivative or the pharmacologically acceptable acid addition salt thereof as the effective ingredient, and comprising sodium thiosulfate, a sugar or a sugar alcohol and hydroxypropylcellulose having a low degree of substitution in an amount of 1 to 30% by weight per weight of a unit containing the effective ingredient.
Public/Granted literature
- US20100120815A1 STABLE SOLID PREPARATION CONTAINING 4,5-EPOXYMORPHINAN DERIVATIVE Public/Granted day:2010-05-13
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