Invention Grant
- Patent Title: A3 adenosine receptor allosteric modulators
- Patent Title (中): A3腺苷受体变构调节剂
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Application No.: US12219772Application Date: 2008-07-28
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Publication No.: US08420664B2Publication Date: 2013-04-16
- Inventor: Aniko Goblyos , Johannes Brussee , Adriaan P. Ijzerman , Zhan-Guo Gao , Kenneth Jacobson
- Applicant: Aniko Goblyos , Johannes Brussee , Adriaan P. Ijzerman , Zhan-Guo Gao , Kenneth Jacobson
- Applicant Address: US DC Washington NL Leiden
- Assignee: The United States of America, represented by the Secretary, Dept. of Health and Human Services,Universiteit Leiden
- Current Assignee: The United States of America, represented by the Secretary, Dept. of Health and Human Services,Universiteit Leiden
- Current Assignee Address: US DC Washington NL Leiden
- Agency: Vorys, Sater, Seymour and Pease LLP
- Agent Susanne M. Hopkins; Ari G. Zytcer
- Main IPC: A61K31/4745
- IPC: A61K31/4745 ; C07D471/04
Abstract:
The present invention relates to allosteric modulation of A3 adenosine receptor (A3AR) and provides for the use of an A3 adenosine receptor modulator (A3RM), for the preparation of pharmaceutical compositions for modulating the A3AR in a subject, as well as pharmaceutical compositions comprising the same and therapeutic methods comprising administering to a subject an amount of an A3RM, the amount being effective to modulate A3AR activity. The A3RM according to the invention are 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives. The invention also provides some of such novel 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives.
Public/Granted literature
- US20090054476A1 A3 Adenosine receptor allosteric modulators Public/Granted day:2009-02-26
Information query
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