Invention Grant
US08420776B2 Ube2G2 binding domain in the ubiquitin ligase gp78 and methods of use thereof
有权
Uub2g2结合域在泛素连接酶gp78及其使用方法
- Patent Title: Ube2G2 binding domain in the ubiquitin ligase gp78 and methods of use thereof
- Patent Title (中): Uub2g2结合域在泛素连接酶gp78及其使用方法
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Application No.: US11597453Application Date: 2005-04-27
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Publication No.: US08420776B2Publication Date: 2013-04-16
- Inventor: Allan Weissman , Jennifer Mariano , Bo Chen , Yien Che Tsai
- Applicant: Allan Weissman , Jennifer Mariano , Bo Chen , Yien Che Tsai
- Applicant Address: US DC Washington
- Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Edwards Wildman Palmer LLP
- Agent Peter F. Corless
- International Application: PCT/US2005/014635 WO 20050427
- International Announcement: WO2006/007023 WO 20060119
- Main IPC: C07K14/435
- IPC: C07K14/435 ; C12P21/02
Abstract:
The present invention features isolated nucleic acid molecules, designated G2BD nucleic acid molecules, which encode the binding site from the gp78 ubiquitin ligase that binds to the Ube2G2 ubiquitin conjugating enzyme. The invention further provides isolated G2BD proteins and fusion proteins. Still further provided are diagnostic and therapeutic methods, as well as screening assays utilizing compositions of the invention.
Public/Granted literature
- US20080090249A1 Ube2g2 Binding Domain in The Ubiquitin Ligase Gp78 And Methods Of Use Thereof Public/Granted day:2008-04-17
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