Invention Grant
- Patent Title: Tetrahydroisoquinolines and intermediates therefor
- Patent Title (中): 四氢异喹啉及其中间体
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Application No.: US12995776Application Date: 2009-06-04
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Publication No.: US08420811B2Publication Date: 2013-04-16
- Inventor: Paul Lobben , Rulin Zhao , Bei Wang , Bang-Chi Chen , Shuang Liu , Min Hu , Yuh-Lin Allen Yang , Matthew Isherwood , Rasidul Amin , Wenge Cui
- Applicant: Paul Lobben , Rulin Zhao , Bei Wang , Bang-Chi Chen , Shuang Liu , Min Hu , Yuh-Lin Allen Yang , Matthew Isherwood , Rasidul Amin , Wenge Cui
- Applicant Address: US NJ Princeton US NY Albany
- Assignee: Bristol-Myers Squibb Company,Albany Molecular Research, Inc.
- Current Assignee: Bristol-Myers Squibb Company,Albany Molecular Research, Inc.
- Current Assignee Address: US NJ Princeton US NY Albany
- Agent Warren K. Volles
- International Application: PCT/US2009/046259 WO 20090604
- International Announcement: WO2009/149259 WO 20091210
- Main IPC: C07D401/04
- IPC: C07D401/04 ; A61P25/24
Abstract:
Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form. One such intermediate has the following structure:
Public/Granted literature
- US20110077400A1 PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES Public/Granted day:2011-03-31
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