Invention Grant
US08420819B2 Process for optimizing the particle size of an active pharmaceutical ingredient by crystallization 有权
通过结晶优化活性药物成分的粒径的方法

  • Patent Title: Process for optimizing the particle size of an active pharmaceutical ingredient by crystallization
  • Patent Title (中): 通过结晶优化活性药物成分的粒径的方法
  • Application No.: US12788562
    Application Date: 2010-05-27
  • Publication No.: US08420819B2
    Publication Date: 2013-04-16
  • Inventor: Soojin Kim
  • Applicant: Soojin Kim
  • Applicant Address: DE Ingelheim am Rhein
  • Assignee: Boehringer Ingelheim International GmbH
  • Current Assignee: Boehringer Ingelheim International GmbH
  • Current Assignee Address: DE Ingelheim am Rhein
  • Agent Michael P. Morris; Timothy X. Witkowski; Usha R. Patel
  • Main IPC: C07D471/04
  • IPC: C07D471/04
Process for optimizing the particle size of an active pharmaceutical ingredient by crystallization
Abstract:
A process to crystallize uniform small particles of a compound of Formula (I) with narrow particle size distribution and excellent powder characteristics that facilitate the formulation process and optimal drug product performance, wherein the compound of Formula (I) is: wherein R1, R2, and R3 are as described herein.
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