Invention Grant
US08420832B2 Optically active methylhydroxylaminopropanol derivative and its use as intermediate for preparation of (S)-(-)-3-methylamino-1-(-2-thienyl)propan-1-ol
有权
光学活性甲基羟基氨基丙醇衍生物及其作为制备（S） - （ - ） - 3-甲基氨基-1-（2-噻吩基）丙-1-醇的中间体的用途
- Patent Title: Optically active methylhydroxylaminopropanol derivative and its use as intermediate for preparation of (S)-(-)-3-methylamino-1-(-2-thienyl)propan-1-ol
- Patent Title (中): 光学活性甲基羟基氨基丙醇衍生物及其作为制备（S） - （ - ） - 3-甲基氨基-1-（2-噻吩基）丙-1-醇的中间体的用途
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Application No.: US13436253Application Date: 2012-03-30
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Publication No.: US08420832B2Publication Date: 2013-04-16
- Inventor: Bo-Fong Chen , Jinun-Ban Yeh , Weichyun Wong
- Applicant: Bo-Fong Chen , Jinun-Ban Yeh , Weichyun Wong
- Applicant Address: TW Taoyuan
- Assignee: Sci Pharmtech, Inc.
- Current Assignee: Sci Pharmtech, Inc.
- Current Assignee Address: TW Taoyuan
- Agency: Sughrue Mion, PLLC
- Main IPC: C07D333/12
- IPC: C07D333/12
Abstract:
The present invention provides an (S)-methylhydroxylaminopropanol compound and the (S)-methylhydroxylaminopropanol compound of the present invention is used as an intermediate for preparation of (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing (S)-(+3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol compound is used as an intermediate.
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