Invention Grant
US08420865B2 Phosphine compound, process for producing the same, and peroxide scavenger using the same
有权
膦化合物,其制备方法和使用该化合物的过氧化物清除剂
- Patent Title: Phosphine compound, process for producing the same, and peroxide scavenger using the same
- Patent Title (中): 膦化合物,其制备方法和使用该化合物的过氧化物清除剂
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Application No.: US12921967Application Date: 2009-03-10
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Publication No.: US08420865B2Publication Date: 2013-04-16
- Inventor: Kosei Shioji , Hiroyuki Nakagawa , Kentaro Okuma
- Applicant: Kosei Shioji , Hiroyuki Nakagawa , Kentaro Okuma
- Applicant Address: JP Fukuoka-shi
- Assignee: Fukuoka University
- Current Assignee: Fukuoka University
- Current Assignee Address: JP Fukuoka-shi
- Agency: Birch, Stewart, Kolasch & Birch, LLP.
- Priority: JP2008-060715 20080311
- International Application: PCT/JP2009/054551 WO 20090310
- International Announcement: WO2009/113543 WO 20090917
- Main IPC: C07F9/54
- IPC: C07F9/54

Abstract:
The invention provides a novel peroxide scavenger comprising a phosphine compound represented by general formula [I]: wherein Z1 and Z2 each represents a cyclic group; Ar represents an arylene group; R represents an aliphatic hydrocarbon group; Y represents phosphorus (P), nitrogen (N), or bismuth (Bi); and R1, R2, and R3 each represents a cyclic group, particularly a peroxide scavenger that can scavenge peroxides such as reactive oxygen species which are generated in mitochondria upon exposure to oxidative stress and localized in mitochondria. The phosphine compound of the invention is oxidized by the peroxides localized in mitochondria to increase the fluorescence intensity, whereby the peroxides can be scavenged.
Public/Granted literature
- US20110015440A1 PHOSPHINE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND PEROXIDE SCAVENGER USING THE SAME Public/Granted day:2011-01-20
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