Presently disclosed is a method for reducing interference in a wireless distributed antenna systems. In an embodiment, interference is reduced by selectively placing a first wireless remote unit in a reduced signal interference mode. A controller sends a signal, such as a reverse link power-down signal, to the first remote unit after detecting less than a threshold incoming signal strength at the first remote unit. In an alternative embodiment, the controller requests that a given remote unit switch to the reduced signal interference mode when the controller is receiving signals from a mobile station through at least two different remote units.