A method and system are illustrated to redirect serial device requests from an application on a computer to a plurality of serial devices connected to the computer via a network. The method and system include receiving serial device requests from one or more applications existing on the computer. Each serial device request may be associated with a specific application protocol and directed to one of the plurality of serial devices over the network. The method and system include determining, for a respective serial device request, an application protocol associated with the respective serial device request and forwarding the respective serial device request as a serial redirector message according to the determined application protocol. The method and system include associating the forwarded serial redirector message with a transport protocol. The method and system further include transmitting the serial redirector message over the network as a function of a transport protocol associated with the serial redirector message.