Disclosed are systems, methods and computer program products for updating antivirus cache during malware scan of a computer system. In particular, an antivirus cache stored in a non-volatile system memory may be updated with information from an antivirus database during execution of malware detection processes launched on the computer system. If a malware detection process use one or more sections of the antivirus cache which require updating, the system replicates those sections of the antivirus cache and updates them. Each update contains different types of data and code associated with different types of malware. During update, the same types of data for each type of malware is collected and stored as data files in corresponding sections of the antivirus cache and executable code sections are converted into platform-specific dynamic libraries and also stored in the antivirus cache.