Invention Grant
US08425845B2 Genetic analysis LOC with hybridization array with calibration chamber containing probe that lacks a reporter
失效
遗传分析具有杂交阵列的LOC，其中含有缺乏报告物的探针的校准室
- Patent Title: Genetic analysis LOC with hybridization array with calibration chamber containing probe that lacks a reporter
- Patent Title (中): 遗传分析具有杂交阵列的LOC，其中含有缺乏报告物的探针的校准室
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Application No.: US13150184Application Date: 2011-06-01
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Publication No.: US08425845B2Publication Date: 2013-04-23
- Inventor: Kia Silverbrook , Mehdi Azimi
- Applicant: Kia Silverbrook , Mehdi Azimi
- Applicant Address: AU Rozelle, New South Wales
- Assignee: Geneasys Pty Ltd
- Current Assignee: Geneasys Pty Ltd
- Current Assignee Address: AU Rozelle, New South Wales
- Main IPC: C40B40/04
- IPC: C40B40/04 ; C40B40/06 ; C12M1/34 ; G01N21/64 ; C12Q1/68 ; G01N33/00 ; G01N1/00 ; G01N21/00 ; B01L3/00 ; C40B60/12
Abstract:
A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, hybridization chambers containing probes that each have a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, a fluorophore and a quencher configured such that the fluorophore emits a fluorescence signal in response to an excitation light and the quencher quenches the fluorescence signal when the probe is not hybridized, but fails to quench the fluorescence signal from the probe-target hybrid, and, a calibration chamber with no fluorophore.
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