Invention Grant
US08426136B2 Epigenetic modifications at TNFα as biomarkers for sensitivity to Smac mimetic-induced apoptosis
有权
TNFα的表观遗传修饰作为Smac模拟诱导凋亡敏感性的生物标志物
- Patent Title: Epigenetic modifications at TNFα as biomarkers for sensitivity to Smac mimetic-induced apoptosis
- Patent Title (中): TNFα的表观遗传修饰作为Smac模拟诱导凋亡敏感性的生物标志物
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Application No.: US12751976Application Date: 2010-03-31
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Publication No.: US08426136B2Publication Date: 2013-04-23
- Inventor: Lai Wang , Brandon L. Probst
- Applicant: Lai Wang , Brandon L. Probst
- Applicant Address: US TX Dallas
- Assignee: Joyant Pharmaceuticals, Inc.
- Current Assignee: Joyant Pharmaceuticals, Inc.
- Current Assignee Address: US TX Dallas
- Agent Richard Aron Osman
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The invention provides a method for determining sensitivity of a cell population to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs, which method comprises assaying for an epigenetic modification at the TNFα locus in the cell population as compared to the TNFα locus in a cell population not sensitive to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs, wherein the presence of the epigenetic modification indicates that the cell population is sensitive to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs.
Public/Granted literature
- US20100279948A1 EPIGENETIC MODIFICATIONS AT TNFalpha AS BIOMARKERS FOR SENSITIVITY TO SMAC MIMETIC-INDUCED APOPTOSIS Public/Granted day:2010-11-04
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