Invention Grant
- Patent Title: Detection of sub-cellular compartment localization of a molecule using a reduced affinity enzyme complementation reporter system
- Patent Title (中): 使用降低的亲和力酶互补报告系统检测分子的亚细胞区室定位
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Application No.: US11964411Application Date: 2007-12-26
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Publication No.: US08426138B2Publication Date: 2013-04-23
- Inventor: Helen M. Blau , Mark Morris Hammer , Tom Wehrman
- Applicant: Helen M. Blau , Mark Morris Hammer , Tom Wehrman
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Peters Verny, LLP
- Agent David J. Aston
- Main IPC: G01N33/573
- IPC: G01N33/573 ; C12Q1/34 ; C12Q1/68 ; C12N5/00 ; C12N1/16
Abstract:
Methods and compositions for detecting the sub-cellular localization of a molecule are provided. Aspects of the invention include detecting translocation of a cell-surface receptor to a sub-cellular compartment, e.g., the endosome, using a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods.
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