Invention Grant
- Patent Title: Inhibition of viral gene expression using small interfering RNA
- Patent Title (中): 使用小干扰RNA抑制病毒基因表达
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Application No.: US13039100Application Date: 2011-03-02
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Publication No.: US08426380B2Publication Date: 2013-04-23
- Inventor: Roger L. Kaspar , Heini Ilves , Attila A. Seyhan , Alexander V. Vlassov , Brian H. Johnston
- Applicant: Roger L. Kaspar , Heini Ilves , Attila A. Seyhan , Alexander V. Vlassov , Brian H. Johnston
- Applicant Address: US CA Santa Cruz
- Assignee: Somagenics, Inc.
- Current Assignee: Somagenics, Inc.
- Current Assignee Address: US CA Santa Cruz
- Agency: Wilson, Sonsini, Goodrich & Rosati
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C07H21/04
Abstract:
The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
Public/Granted literature
- US20110269816A1 Inhibition of Viral Gene Expression Using Small Interfering RNA Public/Granted day:2011-11-03
Information query
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