Invention Grant
US08426398B2 Conjugates of noscapine and folic acid and their use in treating cancer
有权
诺斯卡品和叶酸的结合物及其在治疗癌症中的应用
- Patent Title: Conjugates of noscapine and folic acid and their use in treating cancer
- Patent Title (中): 诺斯卡品和叶酸的结合物及其在治疗癌症中的应用
-
Application No.: US13142908Application Date: 2010-01-08
-
Publication No.: US08426398B2Publication Date: 2013-04-23
- Inventor: Harish C. Joshi , Surya N. Vangapandu , Ritu Aneja
- Applicant: Harish C. Joshi , Surya N. Vangapandu , Ritu Aneja
- Applicant Address: US GA Atlanta
- Assignee: Emory University
- Current Assignee: Emory University
- Current Assignee Address: US GA Atlanta
- Agency: Emory Patent Group
- Agent James C. Mason; Susanne Hollinger
- International Application: PCT/US2010/020472 WO 20100108
- International Announcement: WO2010/083104 WO 20100722
- Main IPC: A01N43/00
- IPC: A01N43/00 ; A01N43/42 ; A61K31/33 ; C07D475/00
Abstract:
The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs), where the folic acid is conjugated to noscapine or the noscapine analog at the 9-position on the isoquinoline ring on the noscapine framework. Pharmaceutical compositions including the compounds, and methods of treating various tumors using the compounds and compositions, are also disclosed. The conjugates are particularly useful for treating cancers which overexpress the Folate Receptor α (FRa) receptor.
Public/Granted literature
- US20110286919A1 CONJUGATES OF NOSCAPINE AND FOLIC ACID AND THEIR USE IN TREATING CANCER Public/Granted day:2011-11-24
Information query
IPC分类:
