Invention Grant
- Patent Title: Heterocyclic pyrazole-carboxamidesas P2Y12 antagonists
- Patent Title (中): 杂环吡唑 - 甲酰胺P2Y12拮抗剂
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Application No.: US12817873Application Date: 2010-06-17
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Publication No.: US08426420B2Publication Date: 2013-04-23
- Inventor: Marc Nazaré , Gernot Zech , Melitta Just , Tilo Weiss , Gerhard Hessler , Markus Kohlmann
- Applicant: Marc Nazaré , Gernot Zech , Melitta Just , Tilo Weiss , Gerhard Hessler , Markus Kohlmann
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP07291627 20071226
- Main IPC: A61K31/496
- IPC: A61K31/496 ; A61K31/454 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D405/14 ; C07D413/14 ; C07D417/14

Abstract:
The present invention relates to compounds of the formula I, wherein R1; R2; Z; A; B; D; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an anti-thrombotic effect and are suitable, e.g., for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible antagonists of the platelet ADP receptor P2Y12, and can in general be applied in conditions in which an undesired activation of the platelet ADP receptor P2Y12 is present or for the cure or prevention of which an inhibition of the platelet ADP receptor P2Y12 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
Public/Granted literature
- US20110021537A1 HETEROCYCLIC PYRAZOLE-CARBOXAMIDESAS P2Y12 ANTAGONISTS Public/Granted day:2011-01-27
Information query
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