Invention Grant
US08426606B2 2′,2-bisthiazole non-nucleoside compounds, preparation methods, pharmaceutical compositions and uses as hepatitis virus inhibitors thereof
失效
2'，2-双噻唑非核苷化合物，制备方法，药物组合物和用途作为其肝炎病毒抑制剂
- Patent Title: 2′,2-bisthiazole non-nucleoside compounds, preparation methods, pharmaceutical compositions and uses as hepatitis virus inhibitors thereof
- Patent Title (中): 2'，2-双噻唑非核苷化合物，制备方法，药物组合物和用途作为其肝炎病毒抑制剂
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Application No.: US13636488Application Date: 2011-03-16
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Publication No.: US08426606B2Publication Date: 2013-04-23
- Inventor: Fajun Nan , Jianping Zuo , Yangming Zhang , Wei Tang
- Applicant: Fajun Nan , Jianping Zuo , Yangming Zhang , Wei Tang
- Applicant Address: CN Shanghai
- Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Current Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Current Assignee Address: CN Shanghai
- Agency: Andrews Kurth, LLP
- Agent Ping Wang
- Priority: CN201010131636 20100324
- International Application: PCT/CN2011/071851 WO 20110316
- International Announcement: WO2011/116663 WO 20110929
- Main IPC: C07D417/04
- IPC: C07D417/04 ; A61K31/427
Abstract:
The present disclosure belongs to the field of pharmaceutical chemistry, and relates to a class of 2′,2-bisthiazole non-nucleoside compounds of following formula I, the preparation method and the pharmaceutical composition thereof. The compounds have both the anti-HBV and anti-HCV activities and are useful in treating hepatitides B and C. Pharmacokinetic tests showed the compounds have good bioavailability.
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