Invention Grant
- Patent Title: Method and apparatus for continuous flow synthesis of ibuprofen
- Patent Title (中): 用于连续流动合成布洛芬的方法和装置
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Application No.: US12868787Application Date: 2010-08-26
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Publication No.: US08426630B2Publication Date: 2013-04-23
- Inventor: D. Tyler McQuade , Andrew Bogdan , Sarah Lihoa Poe
- Applicant: D. Tyler McQuade , Andrew Bogdan , Sarah Lihoa Poe
- Applicant Address: US FL Tallahassee
- Assignee: Florida State University Research Foundation
- Current Assignee: Florida State University Research Foundation
- Current Assignee Address: US FL Tallahassee
- Agency: Alchemy-Partners, PC
- Agent Ajay A. Jagtiani
- Main IPC: C07C69/612
- IPC: C07C69/612

Abstract:
A multi-step method for the continuous synthesis of ibuprofen or a synthetic precursor of ibuprofen is provided that does not require any intermediate purification or isolation steps and uses reagents compatible with downstream reactions. According to some embodiments, a method is provided wherein isobutylbenzene and a propionyl compound may be converted into a first product in a first Friedel Crafts acylation reaction. The first product may then be converted into a second product in a 1,2-aryl migration reaction. Finally, the second product may be converted into ibuprofen in a hydrolysis reaction. The present invention also provides a method wherein only the first and second reaction steps or only the second and third reaction steps are performed. An apparatus is also provided having two or more microreactors and two or more junctions in particular arrangements for the synthesis of ibuprofen or a synthetic precursor of ibuprofen.
Public/Granted literature
- US20110054208A1 METHOD AND APPARATUS FOR CONTINUOUS FLOW SYNTHESIS OF IBUPROFEN Public/Granted day:2011-03-03
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