One embodiment is directed to a distributed antenna system in which a setting for automatic gain control functionality in at least one unit included in the system (for example, in a hub unit or a remote unit) is determined by interpolating between two detected levels measured at that unit while the automatic gain control functionality is operating in two respective predetermined configurations and by interpolating between two target levels that are associated with the two respective predetermined configurations. In one example, the intersection of the two resulting interpolations is used to determine the setting for the automatic gain control functionality.