The invention relates to a measuring device (1) for the non-invasive measurement of physiological parameters. The measuring device (1) is suited to detect and localize by way of self diagnosis diseases such as, for example, inflammations, tumors or arteriosclerosis. The invention proposes a measuring device (1) with at least one optical measuring unit (100) for the generation of oximetric and/or plethysmographic measuring signals, an evaluation unit (140) processing the measuring signals, and a unit (120, 130) for the acquisition of local tissue parameters such as fat content, water content and/or blood perfusion, with the evaluation unit (140) being designed such that at least one local metabolic parameter is determined, in particular the local oxygen consumption, from the signals furnished by the optical measuring unit and obtained from tissue parameters. Moreover, the measuring device (1) enables the non-invasive determination of the blood glucose level.