A miniature microdrive system may be affixed to the skull and used to advance recording electrode bundles or injection cannula through the brain of freely moving test subjects, e.g., rodents. The microdrive may be constructed using a hybrid fabrication technique utilizing a printed circuit board and a small number of mechanical parts. The printed circuit board provides the base for both the electrical components and the mechanical components. The movement of a screw advances a shuttle that in turn moves an electrode bundle through the brain. Independently moving screws advance independent electrode bundles. The electrode wires are connected through the printed circuit board to a connector on the back of the board. Stainless steel cannulae are soldered to a grounding trace on the printed circuit board to guide the electrode bundle and provide a ground connection. With this system, multiple brain structures may be targeted simultaneously. The microdrive system or device is simple to mass produce, making fabrication simple with parts that can be recycled or discarded as needed.