A system, method, and design structure for address-event-representation network simulation are provided. The system includes a hardware structure with a plurality of interconnected processing modules configured to simulate a plurality of interconnected nodes. To simulate each node, the hardware structure includes a source table configured to receive an input message and identify a weight associated with a source of the input message. The hardware structure also includes state management logic configured to update a node state as a function of the identified weight, and generate an output signal responsive to the updated node state. The hardware structure further includes a target table configured to generate an output message in response to the output signal, identify a target to receive the output message, and transmit the output message. The hardware structure may further include learning logic configured to combine information about input messages and generated output signals, and to update weights.