A handling device of a printing press, in particular for handling printing plates during an automated printing plate change on a printing unit of a printing press, is disclosed. The handling device has a manipulator arm, where one end of the manipulator arm is assigned a manipulator head, which features a handling element, in particular a holding element for printing plates, and the manipulator arm is embodied in a multi-part manner of several segments. A swivel axis is embodied on each end of each segment, around which at least the respective segment can be swiveled, and each swivel axis is assigned a separate drive for providing the respective swivel movement. The other end of the manipulator arm is mounted so it is translatorily and rotationally movable on a traverse or on a frame or on a wall of the printing press.