The present invention provides a heat exchange system including, among other things, a radiator operable to remove heat from coolant, an air flow path extending through a first charge air cooler and a second charge air cooler, the first charge air cooler being operable to transfer heat from air to the coolant, the second charge air cooler being positioned downstream from the first charge air cooler along the air flow path to receive the air from the first charge air cooler and being operable to transfer heat from the air to the coolant, and a coolant circuit extending between a coolant pump, the radiator, and the first and second charge air coolers.