A mobile tower drive system for efficiently attaching a removable drive system to a scaffolding unit and driving the scaffolding unit from the work platform. The mobile tower drive system generally includes a lower unit adapted to be secured to a lower end of a scaffolding unit, wherein the lower unit has a wheel to operably engage a floor surface and move between an engaged and disengaged position. The lower unit removably attaches to an upper unit, wherein the upper unit is secured relative the upper frame of the scaffolding unit. Both, the lower unit and the upper unit employ coaxial drives for turning and driving the wheel. The coaxial drive also is used to brake the wheel. The coaxial drives are generally controlled via manually operable rotational control levers; however automated power sources may be utilized. Also disclosed are swivel locks for the caster wheels of the scaffolding unit.