Fluid control device (70) including a housing (31) with a syringe port (33) for receiving a syringe, a vial adapter port (36) with a vial adapter (86) for snap fit receiving a vial, and a drug administration port (34) for administering a liquid drug. The vial adapter is intended to be rotationally detached after a mixing procedure for discarding together with a spent vial. The fluid control device additionally includes a manually depressed actuator (74) for sealing pathways which may lead to leakage of liquid drug subsequent to vial adapter detachment, thereby facilitating their use for handling and administration of hazardous liquid drugs. The manually depressed actuator preferably precludes vial adapter detachment prior to actuation, thereby ensuring failsafe operation.