Invention Grant
- Patent Title: Attenuated FNR deficient enterobacteria
- Patent Title (中): 减少FNR缺陷型肠细菌
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Application No.: US13327420Application Date: 2011-12-15
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Publication No.: US08435506B2Publication Date: 2013-05-07
- Inventor: Hosni M. Hassan , Ryan C. Fink , Matthew R. Evans
- Applicant: Hosni M. Hassan , Ryan C. Fink , Matthew R. Evans
- Applicant Address: US NC Raleigh
- Assignee: North Carolina State University
- Current Assignee: North Carolina State University
- Current Assignee Address: US NC Raleigh
- Agency: Myers Bigel Sibley & Sajovec, P.A.
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K39/112 ; C12N1/36
Abstract:
The invention provides an attenuated enterobacterium comprising an attenuating mutation in the fnr gene, and optionally further comprising a heterologous nucleic acid encoding a foreign antigen. Also provided are pharmaceutical formulations comprising the attenuated enterobacteria of the invention. Further disclosed are methods of inducing an immune response in a subject by administration of an immunogenically effective amount of an attenuated enterobacterium or pharmaceutical formulation of the invention.
Public/Granted literature
- US20120128718A1 ATTENUATED FNR DEFICIENT ENTEROBACTERIA Public/Granted day:2012-05-24
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