Invention Grant
- Patent Title: NOTCH1 receptor antibodies and methods of treatment
- Patent Title (中): NOTCH1受体抗体和治疗方法
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Application No.: US13003013Application Date: 2009-07-08
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Publication No.: US08435513B2Publication Date: 2013-05-07
- Inventor: Austin L. Gurney , Timothy Hoey , Maureen Fitch Bruhns , Fumiko Takada Axelrod
- Applicant: Austin L. Gurney , Timothy Hoey , Maureen Fitch Bruhns , Fumiko Takada Axelrod
- Applicant Address: US CA Redwood City
- Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne Kessler Goldstein & Fox P.L.L.C.
- International Application: PCT/US2009/003995 WO 20090708
- International Announcement: WO2010/005567 WO 20100114
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/00 ; C07K16/18 ; C07K16/28 ; C07H21/04 ; C12N5/00 ; C12N5/10
Abstract:
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
Public/Granted literature
- US20110311552A1 NOTCH1 RECEPTOR BINDING AGENTS AND METHODS OF USE THEREOF Public/Granted day:2011-12-22
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