Invention Grant
US08435523B2 Antibodies against nerve growth factor (NGF) with enhanced in vivo stability
有权
具有增强的体内稳定性的抗神经生长因子（NGF）的抗体
- Patent Title: Antibodies against nerve growth factor (NGF) with enhanced in vivo stability
- Patent Title (中): 具有增强的体内稳定性的抗神经生长因子（NGF）的抗体
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Application No.: US12773488Application Date: 2010-05-04
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Publication No.: US08435523B2Publication Date: 2013-05-07
- Inventor: John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
- Applicant: John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
- Applicant Address: NL Zwolle
- Assignee: Abbott Research B.V.
- Current Assignee: Abbott Research B.V.
- Current Assignee Address: NL Zwolle
- Agency: McAndrews, Held & Malloy, Ltd.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/22
Abstract:
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
Public/Granted literature
- US20100278839A1 ANTIBODIES AGAINST NERVE GROWTH FACTOR (NGF) WITH ENHANCED IN VIVO STABILITY Public/Granted day:2010-11-04
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