Invention Grant
- Patent Title: Collagen/hydroxyapatite composite scaffold, and process for the production thereof
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Application No.: US12526353Application Date: 2008-02-11
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Publication No.: US08435552B2Publication Date: 2013-05-07
- Inventor: Fergal Joseph O'Brien , John Patrick Gleeson , Niamh Plunkett
- Applicant: Fergal Joseph O'Brien , John Patrick Gleeson , Niamh Plunkett
- Applicant Address: IE Dublin
- Assignee: Royal College of Surgeons in Ireland
- Current Assignee: Royal College of Surgeons in Ireland
- Current Assignee Address: IE Dublin
- Agency: Nixon Peabody LLP
- Priority: EP07394001 20070209
- International Application: PCT/IE2008/000010 WO 20080211
- International Announcement: WO2008/096334 WO 20080814
- Main IPC: A61F2/28
- IPC: A61F2/28 ; A61K38/39 ; A61K9/14 ; A61P19/00

Abstract:
A process for producing a collagen/hydroxyapatite (HA) composite scaffold comprises the steps of forming a homogenous suspension of collagen and HA in an acidic solution, lyophilizing the suspension until a desired final freezing temperature is reached to produce the composite scaffold, and optionally cross-linking the composite scaffold, wherein the ratio of HA to collagen is at least 1:10 (w/w). Also provided is a collagen/hydroxyapatite (HA) composite scaffold comprising a homogenous distribution of hydroxyapatite within a porous, crosslinked, collagen matrix, wherein the ratio of HA to collagen is at least 1:10 (w/w). Suitably, the composite scaffold has a porosity of at least 99% (v/v), and a compressive stiffness of at least 0.3 KPa. Composite scaffolds of the invention may be used to provide osteoconductive bone implants and tissue engineering implants.
Public/Granted literature
- US20100158976A1 COLLAGEN/HYDROXYAPATITE COMPOSITE SCAFFOLD, AND PROCESS FOR THE PRODUCTION THEREOF Public/Granted day:2010-06-24
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