Invention Grant
US08435754B2 Method of diagnosing the presence of a tumor in a mammal by assessing CDO expression levels
有权
通过评估CDO表达水平来诊断哺乳动物肿瘤存在的方法
- Patent Title: Method of diagnosing the presence of a tumor in a mammal by assessing CDO expression levels
- Patent Title (中): 通过评估CDO表达水平来诊断哺乳动物肿瘤存在的方法
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Application No.: US13286695Application Date: 2011-11-01
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Publication No.: US08435754B2Publication Date: 2013-05-07
- Inventor: Frederic J. de Sauvage , Hua Tian
- Applicant: Frederic J. de Sauvage , Hua Tian
- Applicant Address: US CA South San Francisco US MA Lexington
- Assignee: Genetech, Inc.,Curis, Inc.
- Current Assignee: Genetech, Inc.,Curis, Inc.
- Current Assignee Address: US CA South San Francisco US MA Lexington
- Agency: Ropes & Gray LLP
- Main IPC: G01N33/574
- IPC: G01N33/574 ; C07K16/28
Abstract:
The present invention provides for a method of using BOC/CDO hedgehog antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.
Public/Granted literature
- US20120128585A1 Method of Diagnosing the presence of a tumor in a mammal by assessing CDO expression level Public/Granted day:2012-05-24
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