Invention Grant
US08435947B2 Endothelial nitric oxide synthase antagonists and uses thereof for inhibiting oxygen toxicity
有权
内皮型一氧化氮合酶拮抗剂及其用于抑制氧毒性的用途
- Patent Title: Endothelial nitric oxide synthase antagonists and uses thereof for inhibiting oxygen toxicity
- Patent Title (中): 内皮型一氧化氮合酶拮抗剂及其用于抑制氧毒性的用途
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Application No.: US13103667Application Date: 2011-05-09
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Publication No.: US08435947B2Publication Date: 2013-05-07
- Inventor: Yunchao Su , Dmitry Kondrikov
- Applicant: Yunchao Su , Dmitry Kondrikov
- Applicant Address: US GA Augusta
- Assignee: Medical College of Georgia Research Institute, Inc.
- Current Assignee: Medical College of Georgia Research Institute, Inc.
- Current Assignee Address: US GA Augusta
- Agency: Pabst Patent Group LLP
- Main IPC: A61K38/06
- IPC: A61K38/06
Abstract:
Compositions and methods for inhibiting the interaction between eNOS and β-actin are provided for use in inhibiting or reducing lung injury from oxygen toxicity. One embodiment provides a synthetic or recombinant polypeptide having the β-actin binding domain of eNOS, wherein the polypeptide inhibits or reduces eNOS activity in lung endothelial cells.
Public/Granted literature
- US20120115785A1 ENDOTHELIAL NITRIC OXIDE SYNTHASE ANTAGONISTS AND USES THEREOF FOR INHIBITING OXYGEN TOXICITY Public/Granted day:2012-05-10
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