Invention Grant
US08435961B2 Methods and compositions for increasing the activity of inhibitory RNA
有权
增加抑制性RNA活性的方法和组合物
- Patent Title: Methods and compositions for increasing the activity of inhibitory RNA
- Patent Title (中): 增加抑制性RNA活性的方法和组合物
-
Application No.: US12821967Application Date: 2010-06-23
-
Publication No.: US08435961B2Publication Date: 2013-05-07
- Inventor: Paul Chang , Anthony Leung , Phillip A. Sharp
- Applicant: Paul Chang , Anthony Leung , Phillip A. Sharp
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology
- Current Assignee: Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge
- Agency: Clark & Elbing LLP
- Agent Kristina Bieker-Brady
- Main IPC: A61K31/70
- IPC: A61K31/70 ; A61K31/00 ; A61K39/395
Abstract:
The invention provides methods for increasing the activity of an inhibitory RNA (RNAi) in a subject requiring administering one or more poly-ADP-ribose polymerase (PARP) inhibitors and/or one or more PARG activators to the subject. The invention also provides methods for increasing the activity of an inhibitory RNA in a cell or cell population requiring contacting a cell or cell population with one or more PARP inhibitors and/or one or more PARG activators. The invention further provides compositions and kits containing one or more PARP inhibitors and/or one or more PARG activators.
Public/Granted literature
- US20110097328A1 METHODS AND COMPOSITIONS FOR INCREASING THE ACTIVITY OF INHIBITORY RNA Public/Granted day:2011-04-28
Information query
