Invention Grant
US08435970B2 Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea
失效
1-环丙基-3- [3-(5-吗啉-4-基甲基-1H-苯并咪唑-2-基)-1H-吡唑-4-基] - 脲的药物组合
- Patent Title: Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea
- Patent Title (中): 1-环丙基-3- [3-(5-吗啉-4-基甲基-1H-苯并咪唑-2-基)-1H-吡唑-4-基] - 脲的药物组合
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Application No.: US12306479Application Date: 2007-06-29
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Publication No.: US08435970B2Publication Date: 2013-05-07
- Inventor: Jayne Elizabeth Curry , Neil James Gallagher , John Francis Lyons , Neil Thomas Thompson
- Applicant: Jayne Elizabeth Curry , Neil James Gallagher , John Francis Lyons , Neil Thomas Thompson
- Applicant Address: GB Cambridge
- Assignee: Astex Therapeutics Limited
- Current Assignee: Astex Therapeutics Limited
- Current Assignee Address: GB Cambridge
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- International Application: PCT/GB2007/002447 WO 20070629
- International Announcement: WO2008/001115 WO 20080103
- Main IPC: A61K31/56
- IPC: A61K31/56 ; A61K31/535 ; A61K31/52 ; A61K31/44 ; A61K31/445
![Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea](/abs-image/US/2013/05/07/US08435970B2/abs.jpg.150x150.jpg)
Abstract:
The invention provides combinations of an ancillary compound and a compound which is a salt of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea selected from the lactate and citrate salts and mixtures thereof. Also provided are crystalline forms of the salts, methods for making the salts and their uses in treating cancers. The invention further provides combinations of an ancillary compound and a compound of the formula (I) as defined in PCT/GB2004/002824 (WO 2005/002552) or a compound of the formula (I′) or a salt, solvate, tautomer or N-oxide thereof, wherein R1, E, A and M are as defined in the claims.
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