Invention Grant
- Patent Title: Use of 2,5-dihydroxybenzenesulfonic acid in the manufacturing of medicines, applicable to the treatment of angiodependent diseases
- Patent Title (中): 2,5-二羟基苯磺酸在制造药物中的应用,适用于治疗依从性疾病
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Application No.: US13169781Application Date: 2011-06-27
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Publication No.: US08435971B2Publication Date: 2013-05-07
- Inventor: Pedro Cuevas Sánchez , Antonio Romero Garrido , Guillermo Gimenez Gallego , Serafin Valverde Lopez , Rosa Maria Lozano Puerto
- Applicant: Pedro Cuevas Sánchez , Antonio Romero Garrido , Guillermo Gimenez Gallego , Serafin Valverde Lopez , Rosa Maria Lozano Puerto
- Applicant Address: US NJ Bridgewater
- Assignee: AmDerma Pharmaceuticals, LLC
- Current Assignee: AmDerma Pharmaceuticals, LLC
- Current Assignee Address: US NJ Bridgewater
- Agency: Servilla Whitney LLC
- Agent Kenneth M. Zeidner
- Main IPC: A61K31/185
- IPC: A61K31/185 ; A61K31/56 ; A01N37/00 ; A01N45/00

Abstract:
The invention relates to the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapaptotic capacities thereof, in the treatment of chronic psoriatic plaques.
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