Invention Grant
US08435983B2 Conformationally restrained epothilone analogues as anti-leukemic agents
有权
构象抑制埃坡霉素类似物作为抗白血病药
- Patent Title: Conformationally restrained epothilone analogues as anti-leukemic agents
- Patent Title (中): 构象抑制埃坡霉素类似物作为抗白血病药
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Application No.: US12532829Application Date: 2008-03-20
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Publication No.: US08435983B2Publication Date: 2013-05-07
- Inventor: Viranga Tillekeratne , Richard A. Hudson , Mamoun Alhamadsheh
- Applicant: Viranga Tillekeratne , Richard A. Hudson , Mamoun Alhamadsheh
- Applicant Address: US OH Toledo
- Assignee: The University of Toledo
- Current Assignee: The University of Toledo
- Current Assignee Address: US OH Toledo
- Agency: MacMillan, Sobanski & Todd, LLC
- International Application: PCT/US2008/003638 WO 20080320
- International Announcement: WO2008/118327 WO 20081002
- Main IPC: C07D401/00
- IPC: C07D401/00 ; C07D405/00 ; C07D403/00 ; C07D217/00 ; A01N43/40 ; A61K31/445 ; A61K31/55
Abstract:
A method for synthesizing anti-leukemic epothilone analogues includes rigidifying a region between the macrolactone ring and the aromatic side-chain. The anti-leukemic compositions are non-naturally occurring epothilone analogue that are rigidified between the macrolactone ring and the aromatic side-chain.
Public/Granted literature
- US20100324094A1 Conformationally Restrained Epothilone Analogues as Anti-Leukemic Agents Public/Granted day:2010-12-23
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