Invention Grant
- Patent Title: Bicycloaniline derivative
- Patent Title (中): 双苯胺衍生物
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Application No.: US12663729Application Date: 2008-06-12
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Publication No.: US08436004B2Publication Date: 2013-05-07
- Inventor: Makoto Bamba , Hidetomo Furuyama , Kenji Niiyama , Toshihiro Sakamoto , Satoshi Sunami , Keiji Takahashi , Fuyuki Yamamoto , Takashi Yoshizumi
- Applicant: Makoto Bamba , Hidetomo Furuyama , Kenji Niiyama , Toshihiro Sakamoto , Satoshi Sunami , Keiji Takahashi , Fuyuki Yamamoto , Takashi Yoshizumi
- Applicant Address: JP Chiyoda-Ku, Tokyo
- Assignee: MSD K.K.
- Current Assignee: MSD K.K.
- Current Assignee Address: JP Chiyoda-Ku, Tokyo
- Agent Joan E. Switzer; David A. Muthard
- Priority: JP2007-159217 20070615
- International Application: PCT/JP2008/061182 WO 20080612
- International Announcement: WO2008/153207 WO 20081218
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519 ; C07D487/00

Abstract:
The invention relates to a compound of a general formula (I): wherein A1 and A2 each mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; R1 means a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; R2 means an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of ═NH or ═O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.
Public/Granted literature
- US20110135601A1 BICYCLOANILINE DERIVATIVE Public/Granted day:2011-06-09
Information query
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