Invention Grant
- Patent Title: Compounds and methods for PKC theta inhibition
- Patent Title (中): 用于PKCθ抑制的化合物和方法
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Application No.: US12561750Application Date: 2009-09-17
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Publication No.: US08436025B2Publication Date: 2013-05-07
- Inventor: Janet Ajioka , Heidi S. Hummel , Rich B. Meyer , John Swindle
- Applicant: Janet Ajioka , Heidi S. Hummel , Rich B. Meyer , John Swindle
- Applicant Address: US WA Seattle
- Assignee: CompleGen Partners, Inc.
- Current Assignee: CompleGen Partners, Inc.
- Current Assignee Address: US WA Seattle
- Agency: Kilpatrick Townsend & Stockton LLP.
- Main IPC: A61K31/136
- IPC: A61K31/136 ; A61K31/4412 ; A61P29/00 ; A61P37/06 ; A61P3/10
Abstract:
The present invention provides a method of selectively inhibiting PKCθ in the presence of PKCδ, by administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I. The present invention also provides a method of inhibiting cytokine synthesis in a T cell, a method of inhibiting T cell proliferation, and a method of inhibiting the replication of and cytokine production by T lymphocytes, while not stimulating or inhibiting the replication of B lymphocytes.
Public/Granted literature
- US20100120869A1 COMPOUNDS AND METHODS FOR PKC THETA INHIBITION Public/Granted day:2010-05-13
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