Invention Grant
- Patent Title: Organic compounds
- Patent Title (中): 有机化合物
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Application No.: US12519697Application Date: 2007-12-14
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Publication No.: US08436035B2Publication Date: 2013-05-07
- Inventor: Christopher Adams , Qi-Ying Hu , Gary Michael Ksander , Julien Papillon
- Applicant: Christopher Adams , Qi-Ying Hu , Gary Michael Ksander , Julien Papillon
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: Dilworth & Barrese, LLP
- Agent Ann R. Pokalsky, Esq.
- International Application: PCT/US2007/025556 WO 20071214
- International Announcement: WO2008/076336 WO 20080626
- Main IPC: A61K31/4174
- IPC: A61K31/4174 ; C07D233/64

Abstract:
The present invention provides a compound of formula I: said compound is inhibitor of aldosterone synthase (CYP11B2), and/or 11 beta-hydroxylase (CYP11B1), and/or aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase, aromatase, or CYP11B1. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, increased formation of collagen, fibrosis and remodeling following hypertension and endothelial dysfunction. Finally, the present invention also provides a pharmaceutical composition.
Public/Granted literature
- US20100048562A1 ORGANIC COMPOUNDS Public/Granted day:2010-02-25
Information query
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