Invention Grant
- Patent Title: Selective anticancer chimeric peptide comprising an EGF receptor-binding peptide and a cytotoxic peptide
- Patent Title (中): 包含EGF受体结合肽和细胞毒性肽的选择性抗癌嵌合肽
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Application No.: US13132580Application Date: 2009-12-03
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Publication No.: US08436137B2Publication Date: 2013-05-07
- Inventor: Koji Kawakami , Masayuki Kohno , Tomohisa Horibe , Oumi Nakajima , Mari Haramoto , Liying Yang
- Applicant: Koji Kawakami , Masayuki Kohno , Tomohisa Horibe , Oumi Nakajima , Mari Haramoto , Liying Yang
- Applicant Address: JP Kyoto
- Assignee: Koji Kawakami
- Current Assignee: Koji Kawakami
- Current Assignee Address: JP Kyoto
- Agency: Seed IP Law Group PLLC
- Priority: JP2008-309176 20081203; JP2009-138729 20090609
- International Application: PCT/IB2009/055476 WO 20091203
- International Announcement: WO2010/064207 WO 20100610
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; C12P21/06 ; C12N1/20 ; C12N15/00 ; C12N5/00 ; C12N5/02 ; C12N15/74 ; A61P35/00 ; C07H21/04

Abstract:
It is an object of the present invention to provide a substance usable as an anticancer agent or DDS, which has intracellular stability, which is capable of evading side effects from functional disorder with respect to normal cells, or which has instantaneous effect. The inventors developed a novel chimeric peptide targeting cancer cells which overexpress EGFR or the like using a binding peptide such as a peptide sequence binding to EGFR, and a lytic peptide sequence, thereby solving such an object. Particularly, by using a chimeric peptide including an EGF receptor-binding peptide or the like and a cytotoxic peptide, this object was solved.
Public/Granted literature
- US20110319336A1 SELECTIVE ANTICANCER CHIMERIC PEPTIDE Public/Granted day:2011-12-29
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