Invention Grant
US08436145B2 Compositions and methods for diagnosing and treating cancer and neurodegenerative diseases related to Beclin-1
失效
用于诊断和治疗与Beclin-1相关的癌症和神经退行性疾病的组合物和方法
- Patent Title: Compositions and methods for diagnosing and treating cancer and neurodegenerative diseases related to Beclin-1
- Patent Title (中): 用于诊断和治疗与Beclin-1相关的癌症和神经退行性疾病的组合物和方法
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Application No.: US13152271Application Date: 2011-06-03
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Publication No.: US08436145B2Publication Date: 2013-05-07
- Inventor: Adi Kimchi , Einat Zalckvar
- Applicant: Adi Kimchi , Einat Zalckvar
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- Agency: Booth Udall Fuller, PLC
- Agent Rodney J. Fuller
- Main IPC: C07K16/00
- IPC: C07K16/00
Abstract:
The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a phospho-mimicking residue and uses thereof for treating cancer and neurodegenerative diseases.
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