Invention Grant
- Patent Title: Amino substituted pyrazines as inhibitors or protein kinases
- Patent Title (中): 氨基取代的吡嗪作为抑制剂或蛋白激酶
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Application No.: US12865359Application Date: 2009-01-28
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Publication No.: US08436171B2Publication Date: 2013-05-07
- Inventor: Annika Jenmalm Jensen , Fredrik Lehmann , Erik Nordling , Vendela Parrow
- Applicant: Annika Jenmalm Jensen , Fredrik Lehmann , Erik Nordling , Vendela Parrow
- Applicant Address: SE Stockholm
- Assignee: Akinion Pharmaceuticals AB
- Current Assignee: Akinion Pharmaceuticals AB
- Current Assignee Address: SE Stockholm
- Agency: White & Case LLP
- Priority: SE0800250 20080201; SE0801185 20080521
- International Application: PCT/EP2009/050931 WO 20090128
- International Announcement: WO2009/095399 WO 20090806
- Main IPC: C07D241/20
- IPC: C07D241/20
Abstract:
The present invention relates to compounds of the general formula (I) wherein R1, R2 and R3 are as defined herein, which can act as inhibitors of protein kinases, specially the Fms-like tyrosine kinase 3 (FLT3). A species illustrative of members of the general formula is The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of hematological malignancies, such as AML, MLL, T-ALL, B-ALL and CMML, myeloproliferative disorders, other proliferative disorders like cancer, autoimmune disorders and skin disorders like psoriasis and atopic dermatitis.
Public/Granted literature
- US20110098310A1 NOVEL COMPOUNDS, USE AND PREPARATION THEREOF Public/Granted day:2011-04-28
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