Invention Grant
- Patent Title: Kinase inhibitor with improved solubility profile
- Patent Title (中): 具有改善溶解度特征的激酶抑制剂
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Application No.: US13551680Application Date: 2012-07-18
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Publication No.: US08436179B2Publication Date: 2013-05-07
- Inventor: Michael R. Michaelides , Michael L. Curtin , James H. Holms , Douglas H. Steinman
- Applicant: Michael R. Michaelides , Michael L. Curtin , James H. Holms , Douglas H. Steinman
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agent Susan L. Steele
- Main IPC: C07D513/02
- IPC: C07D513/02 ; A61K31/44
Abstract:
4-Amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide which inhibits protein kinases such as Aurora-kinases and the VEGFR and PDGFR families of kinases, with an improved aqueous solubility profile, compositions containing 4-amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide and methods of treating diseases using 4-amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide are disclosed.
Public/Granted literature
- US20130023555A1 KINASE INHIBITOR WITH IMPROVED SOLUBILITY PROFILE Public/Granted day:2013-01-24
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