Invention Grant
US08436192B2 2-amino-2-phenyl-alkanol derivatives, preparation thereof, and pharmaceutical compositions containing same 有权
2-氨基-2-苯基 - 链烷醇衍生物,其制备方法和含有它们的药物组合物

  • Patent Title: 2-amino-2-phenyl-alkanol derivatives, preparation thereof, and pharmaceutical compositions containing same
  • Patent Title (中): 2-氨基-2-苯基 - 链烷醇衍生物,其制备方法和含有它们的药物组合物
  • Application No.: US13387462
    Application Date: 2010-07-28
  • Publication No.: US08436192B2
    Publication Date: 2013-05-07
  • Inventor: Jean PachotChristophe Dini
  • Applicant: Jean PachotChristophe Dini
  • Applicant Address: FR Romainville
  • Assignee: Oraxcell
  • Current Assignee: Oraxcell
  • Current Assignee Address: FR Romainville
  • Agency: Harness, Dickey & Pierce, P.L.C.
  • Priority: FR0903750 20090730
  • International Application: PCT/FR2010/051598 WO 20100728
  • International Announcement: WO2011/012810 WO 20110203
  • Main IPC: C07D207/02
  • IPC: C07D207/02 A61K31/40
2-amino-2-phenyl-alkanol derivatives, preparation thereof, and pharmaceutical compositions containing same
Abstract:
Ester derivatives of 2-amino-2-phenyl-alkanol of general formula (I) in which: R1 forms with R3 and the nitrogen and carbon atoms to which they are respectively attached, a heterocycle with 4 to 7 members, optionally substituted in the α position of the nitrogen atom by one or two Ra and Rb radicals being able to be independently of one another hydrogen or linear or branched alkyl (1 to 4C), and R2 is H or a —CO—O—CHR4—OCOR5 radical for which R4 is H or linear or branched alkyl (1 to 4C), and R5 is alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by the remainder of an amino acid, or represents a heterocycle, or R2 is linear or branched alkyl (1 to 4C), alkyl (2 to 4C) substituted by OH, alkoxy, alkylthio, NH2, alkylamino, dialkylamino optionally forming with the nitrogen atom to which they are attached, a heterocycle with 5 or 6 members, it being understood that the substituted alkyl radical is linear or branched and comprises at least 2C between >N—R2 and the substituent, unless specified otherwise, alkyl or acyl are linear or branched (1 to 7C), in their R or S forms or their mixtures, as well as its pharmaceutically acceptable salts, if any.
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