A multi-lamp driving system includes a filter circuit, a switch circuit, a pulse width modulation (PWM) controller, a protection circuit, transformers, and an abnormity detection circuit. Primary windings of the transformers are connected to the switch circuit in parallel, and high voltage terminals of secondary windings of the transformers are connected to lamps respectively. The abnormity detection circuit converts current signals flowing through the lamps into voltage signals, and retrieves highest and lowest voltage signals corresponding to highest and lowest current signal respectively. Then the abnormity detection circuit determines if a difference between the highest voltage signal and the lowest voltage signal exceeds a predetermined value, and generates a trigger signal if the difference between the highest and lowest voltage signals exceeds the predetermined value. The protection circuit receives the trigger signal, and controls the PWM controller to stop outputting PWM signals to the switch circuit.